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Amgen Scholars: Announcements of Opportunity

Below are Announcements of Opportunity posted by Caltech faculty for the Amgen Scholars program.

Announcements of Opportunity are posted as they are received. Please check back regularly for new AO submissions! Remember: This is just one way that you can go about identifying a suitable project and/or mentor. For additional tips on identifying a mentor click here.

Please remember:

  • Students pursuing Amgen must be U.S. citizens, U.S. permanent residents, or students with DACA status.
  • Students pursuing Amgen must complete the 10-week program from June 18 - August 23, 2024. Students must commit to these dates. No exceptions will be made.
  • Accepted students must live in provided Caltech housing.

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Project:  Design of Next-Generation 6D Single-Molecule Imaging Systems
Disciplines:  Electrical Engineering, Physics, Information and Data Sciences
Mentor:  Matthew Lew, Associate Professor, (EAS),, Phone: 314-935-6790
Mentor URL:  (opens in new window)
Background:  NOTE: This project is being offered by a Caltech alum and is open only to Caltech students. The project will take place at Washington University in St. Louis in St. Louis, Missouri. From the mentor: "I graduated from Caltech with a BS in EE in 2008. I have advised two Caltech SURF students in previous years and had a great time; both are now enrolled in PhD programs. I'm looking forward to working with passionate and inquisitive students this summer!"

Over the past few years, my lab has published a series of new microscope designs for imaging both the 3D positions and 3D orientations of fluorescent molecules--6D imaging systems. These technologies enable biophysicists to explore simultaneously both where a molecule is and what its conformational state is. Recent advances in mathematical and computational frameworks open a plethora of new possibilities for microscope designs.
Description:  The student will work closely with me and a PhD student in my lab to explore new strategies for microscope design, validate the performance of the new designs, and demonstrate the new microscope for single-molecule imaging of proteins and/or RNA. The student will work at the intersection of Fourier optics, numerical optimization, detection and estimation theory, and single-molecule spectroscopy. The project's emphasis will be tailored to the strengths and interests of the student.

O. Zhang, Z. Guo, Y. He, T. Wu, M. D. Vahey, and M. D. Lew, “Six-dimensional single-molecule imaging with isotropic resolution using a multi-view reflector microscope,” Nat. Photon. 17, 179 (2023).
Student Requirements:  Ma 1 abc, Ph 1 abc, Ph 2 a (waves). ACM 95 ab, EE 55, EE 111, or EE 151 would be beneficial but not required.
Programs:  This AO can be done under the following programs:

  Program    Available To
       SURF    Caltech students only 

Click on a program name for program info and application requirements.

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