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Amgen Scholars: Announcements of Opportunity

Below are Announcements of Opportunity posted by Caltech faculty for the Amgen Scholars program.

Announcements of Opportunity are posted as they are received. Please check back regularly for new AO submissions! Remember: This is just one way that you can go about identifying a suitable project and/or mentor. For additional tips on identifying a mentor click here.

Please remember:

  • Students pursuing Amgen must be U.S. citizens, U.S. permanent residents, or students with DACA status.
  • Students pursuing Amgen must complete the 10-week program from June 17 - August 22, 2025. Students must commit to these dates. No exceptions will be made.
  • Accepted students must live in provided Caltech housing.


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Project:  Quality control of mitochondria
Disciplines:  Biology, Bioengineering
Mentor:  David Chan, Professor of Biology, (BBE), dchan@caltech.edu, Phone: x2670
Mentor URL:  https://chanlab.caltech.edu  (opens in new window)
Background:  Mitochondria are essential organelles that generate energy for cells through oxidative phosphorylation. A typical cell can have hundreds of mitochondria, and the function of this population of mitochondria must be maintained. A major mechanism that maintains mitochondrial function is mitophagy, the selective degradation of defective mitochondria by autophagy. We have identified a new mitophagy pathway, and this project involves understanding its molecular mechanism.
Description:  We are interested in understanding how defective mitochondria are selectively recognized and tagged in the cell. The student will use cell biological techniques to identify how quality-sensing molecules recognize defective mitochondria.
References:  https://www.sciencedirect.com/science/article/pii/S2468867322001304
Student Requirements:  Basic molecular and cell biology
Programs:  This AO can be done under the following programs:

  Program    Available To
       Amgen Scholars    Non-Caltech students only  

Click on a program name for program info and application requirements.


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