Announcements of Opportunity
SURF: Announcements of Opportunity
Below are Announcements of Opportunity posted by Caltech faculty and JPL technical staff for the SURF program. Each AO indicates whether or not it is open to non-Caltech students. If an AO is NOT open to non-Caltech students, please DO NOT contact the mentor. Announcements of Opportunity are posted as they are received. Please check back regularly for new AO submissions!
Remember: This is just one way that you can go about identifying a suitable project and/or mentor. Click here for more tips on finding a mentor. Announcements for external summer programs are listed here.
*Students applying for JPL projects should complete a SURF@JPL application instead of a "regular" SURF application.
*Students pursuing opportunities at JPL must be U.S. citizens or U.S. permanent residents.
<< Prev
Record
49 of
50
Next >>
Back To List
Project: | Structural and Function Characterization of Mega Assemblies | ||||||||||||
Disciplines: | Biochemistry, Structural Biology, Cell Biology | ||||||||||||
Mentor: |
Andre Hoelz,
Ferkel Professor of Chemistry and Biochemistry, (CCE),
hoelz@caltech.edu, |
||||||||||||
Mentor URL: | http://ahweb.caltech.edu/AH_Web/Hoelz_lab_home.html (opens in new window) | ||||||||||||
Background: |
In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and transition in the cytoplasm imposes the requirement of transporting thousands of macromolecules between these two compartments. Nuclear pore complexes (NPCs) are the sole gateways that facilitate this macromolecular exchange across the nuclear envelope with the help of soluble transport receptors. Whereas the mobile transport machinery is reasonably well understood at the atomic level, a commensurate structural characterization of the NPC has not been achieved. Our lab carries out structure-function studies of the nuclear pore complex with the ultimate goal of elucidating its entire atomic structure - the applied structure determination as well as the design principles. |
||||||||||||
Description: | The student will work with a graduate student or postdoctoral fellow to purify and crystallize protein complexes and to carry out functional analyses in yeast. | ||||||||||||
References: |
Lin, D.H., Hoelz, A. (2019). The Structure of the Nuclear Pore Complex (An Update). Annu. Rev. Biochem.88, 725-783. Lin, D.H., Stuwe, T., Schilbach, S., Rundlet, E.R., Perriches, T., Mobbs, G., Fan, Y., Thierbach, K., Huber, F.M., Collins, L.N, Davenport, A.M., Jeon, Y.J., Hoelz, A. (2016). Architecture of the symmetric core of the nuclear pore. Science, 352, 308. [cover] Stuwe, T.T., Bley, C.J. , Thierbach, K., Petrovic, S., Schilbach, S., Mayo, D.J., Perriches, T., Rundlet, E.J., Jeon, Y.J., Collins, L.N., Huber, F.M., Lin, D.H., Paduch, M., Koide, A., Lu, V., Fischer, J., Hurt, E., Koide, S., Kossiakoff, A., Hoelz, A. (2015). Architecture of the fungal nuclear pore inner ring complex. Science, 350, 56-64. Stuwe, T.T., Correia, A.R., Lin, D.H., Paduch, M., Lu, V.T., Kossiakoff, A., Hoelz, A. (2015). Architecture of the nuclear pore complex coat. Science, 347, 1148-1152. |
||||||||||||
Student Requirements: | Prior laboratory experience in structural biology laboratory would be beneficial but is not required. | ||||||||||||
Programs: |
This AO can be done under the following programs:
|
<< Prev Record 49 of 50 Next >> Back To List