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SURF: Announcements of Opportunity

Below are Announcements of Opportunity posted by Caltech faculty and JPL technical staff for the SURF program. Additional AOs for the Amgen Scholars program can be found here.

Specific GROWTH projects being offerred for summer 2018 can be found here.

Each AO indicates whether or not it is open to non-Caltech students. If an AO is NOT open to non-Caltech students, please DO NOT contact the mentor.

Announcements of Opportunity are posted as they are received. Please check back regularly for new AO submissions! Remember: This is just one way that you can go about identifying a suitable project and/or mentor.

Announcements for external summer programs are listed here.

Students pursuing opportunities at JPL must be
U.S. citizens or U.S. permanent residents.

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Project:  Cancer Genome Evolution
Disciplines:  Multidisciplinary, Physical Sciences, Computational Biology, Engineering and Applied Sciences
Mentor:  Cheng-Zhong Zhang, Assistant Professor of Biomedical Informatics, (BBE),, Phone: 617-582-9886
Mentor URL:  (opens in new window)
Background:  NOTE: This project is being offered by a Caltech alumnus. The project will be conducted at Harvard Medical School/Dana Farber Cancer Institute.

My laboratory is interested in the mechanisms causing genome instability and the roles of chromosomal abnormalities in tumorigenesis. We use three approaches to address these questions. First, we develop computational methods to analyze chromosomal alterations (copy-number alterations and chromosomal rearrangements) in cancer genomes and identify their mutational signatures. Second, we design experimental and analytical methods of single-cell genomics as an unbiased and high-throughput assay to study the mechanisms causing chromosomal alterations and their transcriptomic consequences. Finally, by combining single-cell genomics with cell biology and genome engineering, we try to clarify the relationship between chromosomal alterations and cancer hallmarks, and use this knowledge to create new strategies of cancer diagnosis and treatment.
Description:  Students will have the opportunity to be involved in all three areas of research in my laboratory. I especially welcome students in physical and engineering sciences who want to apply computational and statistical methods to analyzing quantitative biological experimental data.
Student Requirements:  programming, statistics, basic molecular biology & genetics
Programs:  This AO can be done under the following programs:

  Program    Available To
       SURF    Caltech students only 

Click on a program name for program info and application requirements.

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