Project:	Membrane Protein Biogenesis
Disciplines:	Biology, Biochemistry
Mentor:	Rebecca Voorhees, Dr., (BBE), voorhees@caltech.edu, Phone: 6263951287
Mentor URL:	https://voorheeslab.caltech.edu/  (opens in new window)
Background:	The goal of this lab is to understand the molecular mechanisms of membrane protein biogenesis and quality control. Interactions in the endoplasmic reticulum (ER) and the mitochondria are a particular focus for the group.
Description:	We use a combination of structural and functional techniques to isolate specific proteins and characterize their function within the cell. Broadly, students will aid the lab in reconstituting cell pathways and protein interactions in vitro, as well as structural analysis of the proteins using imaging equipment. Students can anticipate learning a variety of molecular biology techniques such as PCR, DNA cloning and gel electrophoresis.
References:	WNK1 is an assembly factor for the human ER membrane protein complex https://doi.org/10.1016/j.molcel.2021.04.013
Student Requirements:	N/A
Programs:	This AO can be done under the following programs:   Program    Available To        SURF    Caltech students only  Click on a program name for program info and application requirements.